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Description
What is Plan J
Furthermore, several investigations suggested that ascorbate might directly repair H 2 O 2 -induced DNA alterations such as 8-oxoG and DNA strand break levels [173]
Indeed, systemic administration of clinically relevant doses of EA, a GST inhibitor [45], increased the intra-tumoural GSH levels (Figure 6c) and re-sensitised EGFRm/T790M tumours to erlotinib in a cancer cell xenograft mice model (Figure 6ac)
Pang Z, Chong J, Zhou G, de Lima Morais DA, Chang L, Barrette M
The second approach is blind to mechanisms of action and based on the in vitro screening of compounds from libraries
