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Description
Annals of Neurology, 56 , 149162
It usually reflects cumulative stress on detoxification and antioxidant systems
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase
Long-term safety data is lacking, so potential unknown side effects may exist.
Indeed, probenecid protects isolated kidney cells from toxic mercapturates derived from haloalkenes and hydroquinones (Koob et al., 1990)
