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Activation of P2X7 promotes astrocyte differentiation, and astrocytes can secrete D-serine, a co-agonist at NMDARs, to enhance both homo- and heterosynaptic long-term potentiation (LTP (146))

About half of the inhibitory synapses in the spinal cord use glycine, and research has shown that when glycine is not properly metabolized it can result in an increased risk for developmental problems, lethargy, seizures and mental deficiencies

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5A, C), although mCTSD levels remained above the cutoff level