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It isnt clear if these are direct or indirect effects, but the peptide produces a significant pain-relieving effect that is dose dependent

We also acknowledge Biorender.com ( Figure 1 )

Copper normally travels bound to proteins like ceruloplasmin, but GHKs tripeptide chain has a particularly high affinity for copper (II) ions, forming a stable chelate complex that can shuttle copper efficiently into cells

11 The same researchers also investigated the amino acid sites of haptenation to human serum albumin for three structurally different contact sensitizers and found that conjugates to lysine and even arginine were far more common than to cysteine, especially after longer incubation times such as two and four weeks

Given the essentiality of KIN-19, we focused our investigation on its functional role