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A topical numbing cream is applied before the procedure, and many of the fillers used contain lidocaine for additional comfort during injection

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While MPHs US Food and Drug Administration (FDA) label does not contain pharmacogenomic biomarkers, a lot of research has been performed on the impact of genotype on MPH efficacy, and several biological pathways have been suggested to potentially affect MPH mechanisms through patient genotype, mostly concerning monoamine pathways [4348]

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[DOI] [Google Scholar] Neural efficiency of experts brain during judgment of actions: a high-resolution EEG study in elite and amateur karate athletes