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In darker skin tones (Fitzpatrick types IV to VI), PIH can be significantly more pronounced and take considerably longer to fade

[DOI] [PubMed] [Google Scholar] 137.Gan J., Ruan Q., He B., Zhu M., Shyu W.C., Humphreys W.G

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However, ALDH2-deficient people who do not carry this ADH variant are at the highest risk of cancer as these risk factors act in a multiplicative manner through increasing exposure time to salivary acetaldehyde