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Keep in mind that were not talking about creatures that will gain you life through other means, like entering the battlefield or death triggers, just those with the lifelink keyword

Need to kill a creature

Instantly recognizable, the psychic-type Mewtwo was created when a scientist altered its original DNA via gene-splicing techniques that transformed the creature into one of the most vicious and savage of all Pokmon

This applies whether they go the graveyard, are returned to hand, exiled or removed in any other way

Effects like Duress specifically interact with cards in your hand, and thats the only zone the game recognizes for discarding