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Despite demonstrating biological activity and a favorable safety profile, AOD9604 has not achieved regulatory approval as an obesity therapeutic

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In order to investigate the relationship between metformin and the microbiota, one group of researchers developed a modulator of the microbiome to attempt to shift the GI microflora of that observed in T2DM to one more typical of healthy individuals

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[190] The EMA clarified that the second dose should be administered three weeks after the first dose