glp-1 agonists and sglt2 inhibitors receptor inhibitors: a couple at last? Criteria for recommendation of SGLT2

The NTS itself contains GLP-1 producing neurons which signal to decrease food-based reward in the mesolimbic VTA and NAc, which in turn impact memory and emotional processing in the hippocampus and amygdala [40]

These peptides, including ghrelin, Peptide YY (PYY), and serotonin, are also known as brain-gut mediators

Observational research presented in March 2026 at the American Academy of Orthopaedic Surgeons annual meeting found that GLP-1 drugs may slightly increase the risk of developing osteoporosis and gout, a kind of inflammatory arthritis caused by a buildup of uric acid

Benjamin Bert, MD , a board-certified ophthalmologist at MemorialCare Orange Coast Medical Center in Fountain Valley, California, added that as GLP-1s help with controlling blood sugar, their use may also lead to changes in vision prescription

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