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S., Fitzsimons H

Although more difficult to discriminate in neurons, exendin(9-39) appeared not to be internalized in neurons in the ARC either, as was observed with the antagonist in cells. Finally, a comparative analysis using exendin(9-39) to block GLP-1R in the ARC showed that antagonizing the ARC, rather than the PVN, significantly reduced liraglutide's weight-loss effects, confirming the ARC as the primary target for long-term weight reduction

For policymakers, the influx of generics presents both an opportunity and a responsibility

These include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist

For each parameter, the mean difference or ratio of means was calculated