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doi: 10.3389/fmed.2025.1710960 Received 22 September 2025 Revised 10 November 2025 Accepted 30 November 2025 Published 07 January 2026 Volume 12 - 2025 Edited by Shisan (Bob) Bao, The University of Sydney, Australia Reviewed by Xiaoqing Cathy Cheng, Washington University in St