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References Stout KK, Daniels CJ, Aboulhosn JA, et al
No peer-reviewed clinical trials have demonstrated safety or efficacy of concurrent semaglutide-tirzepatide use, which means prescribers lack evidence to support this combination
These drugs are known to cause extreme nausea, vomiting, diarrhea, and gastroparesis
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In clinical trials, most participants who experienced even moderate GI symptoms were able to continue with appropriate management
