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Preclinical animal and in vitro studies are largely acute, yet chronic exposure better reflects real-world use 16 and may reveal mechanisms of fibrosis, tissue remodeling, and oxidative stress

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Furthermore, use of charcoal filters may introduce additional threats to health associated with inhaling charcoal filter debris

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2 A typical e-cigarettealso called a vapecomprises a battery, a heating element, and a liquid reservoir
