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We confirmed that ROCK was activated in smokers and that ROCK activity was significantly correlated with FMD in smokers [85,86,87]

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Consistent with the human data, third hand smoke for 4 weeks in mice increased inflammatory cytokines in plasma and increased epinephrine and aspartate aminotransferase, a biomarker of liver damage ( 6 Conclusion The above studies of SHS exposure in animals and humans demonstrate that the brain is a key target of nicotine and other constituents following exposure to tobacco products

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