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In vertebrates, nAChRs play a significant role in modulating glutamatergic, GABAergic, and dopaminergic neurotransmission (Feduccia et al., 2012)
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Another limitation is that we used the PY method when expressing smoking amount

Chronic tolerance requires years to develop, and may not change even after years of abstinence (Perkins et al

Tobacco control aims at reducing the use of tobacco and the serious health risks and mortality it causes through policies, laws and education
