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February 25, 2026: Zepbound Label Updated with Warning of Severe Gastrointestinal Issues The FDA has posted an updated Zepbound warning label, which includes reports of gastrointestinal issues that patients claim they experienced after Zepbound reached the market

The early phase begins within minutes of eating, when nutrients in the upper gastrointestinal tract trigger neural and hormonal signals that stimulate L-cells even before food reaches the distal intestine

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