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Furthermore, retrospective cohort studies identified a 1238% prevalence of pre-transplant DM [8,9,10]

Evaluated by fasting blood glucose, the network meta-analysis enrolled 47 randomised controlled trials with 17 163 subjects, confirming the placebo controlled effectiveness of all the 15 GLP-1RAs (fig 4, fig 5)

Future research focusing on the development of nonpeptidergic ligands that could possibly modify the activity of the GLP-1R itself, maximizing the potent effects of GLP-1R agonists at multiple levels, could possibly offer greater benefits in the treatment of PD, as well as of other neurodegenerative diseases

For patients interested in GLP-1 medications specifically for type 2 diabetes rather than weight management, the path is often simpler

Diabetes Control Complications Trial Research Group , Nathan DM, Genuth S, et al