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The SURPASS clinical trial program demonstrated that tirzepatide at its highest dose (15 mg weekly) produced average weight loss of 20-25% of body weight, significantly exceeding the results seen with GLP-1 only agonists

In addition, emerging molecular targets such as AMP-activated protein kinase activators, mammalian target of rapamycin inhibitors, and IR substrate modulators are under investigation

They may lower the dosage of pain medication to prevent some side effects, for example, or remove preservatives or dyes that may cause an allergic reaction

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