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However, when exenatide's action was blocked, their brain responses and eating behavior resembled those in the placebo condition

Ali AM, Martinez R, Al-Jobori H, Adams J, Triplitt C, DeFronzo R, et al

And this is a pilot too

The authors recommend regular monitoring of their use, health outcomes, and broader impacts on the British healthcare system, and to ensure that they are provided safely, appropriately, sustainably and fairly

A 2023 study published in The Journal of Clinical Endocrinology & Metabolism found that men with obesity taking tirzepatide experienced significant increases in total testosterone levels as they lost weight