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When Bariatric Surgery May Be More Appropriate BMI 3540+: Surgical options such as sleeve gastrectomy or gastric bypass typically deliver greater and more durable weight loss for higher-BMI patients

Tirzepatide, a dual GIP and GLP-1 receptor agonist approved by the FDA, has demonstrated cardiovascular safety in large clinical trials without evidence of pathological cardiac atrophy

Platform-by-platform comparison Several patterns emerge from this comparison

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Biological Mechanisms: Why Body Weight Becomes a Defended Setpoint Regulatory biology theory suggests the body defends a physiological setpoint for body weight through complex hormonal feedback