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The SURPASS-1 trial demonstrated significant improvements in glycemic control and substantial reductions in body weight with all three doses of tirzepatide (5 mg, 10 mg, or 15 mg) compared to placebo over a 40-week period

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Clinical studies generally suggest that tirzepatide may lead to more significant weight loss because it targets two hormones (GIP and GLP-1) instead of just one

Retatrutide is designed to activate these three receptors in a way that affects appetite, fullness, glucose control and metabolism

In 2023, Reed weighed 287 pounds