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Results: Our cohort included 2,405 patients (mean[SD] age 48[10], 53% female), with a BMI[SD] of 37[8] kg/m 2 and a mean baseline weight of 238[54] lbs

(2011) compared mindfulness meditators, who had thousands of hours of practice, to non-meditators during fMRI scans [16]

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The four key mechanisms: Brain appetite centers: Reduces food noise the constant mental preoccupation with food and cravings that many patients describe as their biggest challenge Gastric emptying: Slows how quickly food leaves the stomach, producing prolonged fullness after smaller meals Insulin response: Stimulates insulin release when blood sugar rises improving glucose management without causing low blood sugar on its own Glucagon suppression: Reduces glucagon, a hormone that signals the liver to release stored sugar unnecessarily 2