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The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events

As a renowned prescription medication, Semaglutide not only aids in weight loss but also plays a pivotal role in reducing the risk of stroke, heart attack, and mortality in individuals with heart disease or type 2 diabetes

Real-time measurements of dopamine via fiber photometry revealed specific dopamine changes in the nucleus accumbens at both the beginning and end of running bouts, with SG-treated animals showing amplified dopamine dynamics at these key behavioral timepoints
