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Beyond T2D and weight management in individuals with overweight or obesity, GLP-1 receptor agonists are approved for metabolic dysfunction associated steatohepatitis in people with moderate or advanced fibrosis, obstructive sleep apnea in obese adults, reduction of major adverse cardiovascular events in adults with T2D and cardiovascular disease (CVD), and slowing progression of chronic kidney disease and cardiovascular mortality in adults with both chronic kidney disease and T2D

Current models suggest that cumulative emissions of ~1,000 Gt CO are associated with approximately 0.45C of global mean temperature increase over long-term equilibrium [13]

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Its effectiveness depends entirely on correct dosing and pharmaceutical-grade preparation

however, a new paradigm for HFpEF development proposes that a systemic proinflammatory state, induced by comorbidities, is responsible for these myocardial structural and functional changes [11]