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Liraglutide is endogenously metabolized in a similar manner to large proteins without a specific organ as a major route of elimination

Yet the context in which these therapies are prescribed has diverged sharply

10.1371/journal.pone.0181880 12 BnemannM.GerhardsteinB

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According to the Summary of Product Characteristics (SmPCs), GLP-1 medications commonly cause nausea (reported in approximately 20-40% of patients with semaglutide and 12-21% with dulaglutide), vomiting, and diarrhoea, particularly during initial treatment and dose escalation