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These findings have led to the hypothesis that basal levels of autophagy are required for the pluripotency acquired by CSCs

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Mounjaro is typically initiated at 2.5 mg weekly and titrated gradually to higher doses (5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg) based on tolerability and response

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These findings elevated semaglutide from a weight loss tool to a disease-modifying therapy with potential long-term health benefits, explaining its rapid adoption across clinical settings
