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PIONEER 1: Randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with type 2 diabetes

Lingvay I, Mosenzon O, Brown K, Cui X, ONeill C, Fernndez Land L, et al

In addition, Apolipoprotein B, or ApoB was reduced by 15-17% This atherogenic particle is sort of the main driver of cardiovascular disease, and that level of reduction should absolutely provide meaningful benefits in cardiovascular disease

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Major cardiovascular events, heart failure, and atrial fibrillation in patients treated with glucagon-like peptide-1 receptor agonists: An updated meta-analysis of randomized controlled trials