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PMID: 41433034, PMCID: PMC12728728, DOI: 10.1001/jamacardio.2025.4824.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHospital admissionSerious adverse eventsRandomized clinical trialsEstablished CV diseaseCV diseaseSemaglutide groupRate of hospital admissionsAdverse eventsClinical trialsReduction of hospital admissionsDuration of hospital stayImpact of semaglutideBody mass indexTotal hospital admissionsEstablished cardiovascular diseaseEffect of semaglutideCV risk reductionOnce-weekly semaglutideAssociated with significant reductionsMain OutcomesMass indexPlacebo groupPatient yearsTotal hospitalHospital stay FDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/Obesity Do D, Murugiah K, Sawano M, Cartwright B, Rodriguez P, Gratzl S, Curtis L, Jastreboff A , Lu Y, Stucky N

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Speaking to a Healthcare Professional About Retatrutide Your GP is the appropriate first contact for weight management support

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However, long-term use also requires monitoring for gastrointestinal side effects and changes in mood