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True tolerance requiring dose increases happens in a small percentage of patients but isnt the norm
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"A lot of people like the ease of taking a medication once a week," she said
Now, robust clinical trial data are catching up to these observations

Therefore, in GLP-1R KO mice, compensation mechanisms of other receptors may exist to balance the cAMP-mediated downstream signaling pathway to maintain normal survival and activities of the GLP-1R KO mice
