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Studies show GLP-1s help decrease weight, improve metabolic complications, lower flares and stiffness, and may slow joint damage when combined with DMARDs or biologics

The study, published in Nature Health , covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes

Consistent with other GLP1R agonists, nausea, diarrhea and vomiting are common side-effects, with no long-term harms noted from Trulicity over its 9 year use in the markets

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These divergent effects appear to be modulated by multiple factors, including treatment duration, drug concentration, cancer type, and patient-specific parameters such as genetic background and comorbidities [9, 19]