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The onset of diabetes mellitus in chronic pancreatitis is recognized as having a gradual course of progression that is multiplex in nature, with an initial stage involving preserved or mildly lowered C-peptide secretion, with driving hepatic inflammation, chronic in nature, as the primary factor in an insulin resistant state

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[16] In some cases, switching to an alternative agent with different pharmacokinetic properties or discontinuing therapy may be necessary if symptoms significantly impair quality of life or pose health risks

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[1] [2] Traditionally administered via subcutaneous injection, some research has explored transdermal patch delivery systems as an alternative route of administration