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Prescription Options for Severe Nausea For some individuals, the nausea experienced during the dose-escalation phase is disruptive to daily life

Your prescriber will review your current blood pressure readings and medications before deciding whether phentermine is appropriate, and will want to monitor blood pressure more frequently during treatment if it is prescribed

Journal of Applied Physiology, 1997

TGR5 and Its Physiologic Effects Relevant to GLP-1 and Glycogen Metabolism Takeda G protein-coupled receptor 5 (TGR5), a G protein-coupled bile acid receptor, contributes to improved hepatic insulin sensitivity and subsequent energy metabolism and homeostasis [139]

Some dose-dependent increases were observed at higher doses compared to placebo, but these remained within normal ranges and did not indicate pathological C-cell stimulation