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Description
Depending on the route of administration (and the GLP-1R agonist used), peripherally administered GLP-1 analogs seem either to act directly in the hypothalamus and hindbrain, both areas with incomplete BBB, or else on vagal afferents to transmit the signal to the hindbrain which then projects to other key feeding areas in the brain

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PPG NTS neurons are thus the crucial component of the central GLP-1 system, which they comprise along with numerous populations of GLP-1 receptor (GLP-1R)-expressing neurons found throughout the brain 11,12
Mild nausea is common, usually appearing within 12 to 24 hours of injection and resolving within a day or two
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