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This means many patients face a choice between indefinite medication use with its ongoing financial costs and health considerations, or accepting that some or most weight may return after discontinuation

"We have some insane, exciting products that we have worked on for a very long time," Huck said

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Therefore, drugs with a potent antihyperglycemic effect, independent of the glomerular filtration rate, with a low risk of hypoglycemia, that reduce weight in overweight/obese patients and that provide cardiovascular and renal protection, such as GLP-1 receptor agonists, are needed

Gou S, Zhu T, Wang W, Xiao M, Wang XC, Chen ZH