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Those who continued on tirzepatide experienced additional weight loss instead

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Elevated cAMP activates protein kinase A (PKA), which enhances glucose-dependent insulin gene expression and secretion while suppressing glucagon release [15,16]

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GLP-1Rs are expressed throughout the gut-immune-brain network, enabling GLP-1RAs to restore homeostasis at multiple levels

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Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults

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Specifically, the HR for HHF was 0.20 (95% CI 0.070.60) with GLP-1RAs and 0.77 (95% CI 0.640.92) without GLP-1RAs ( P -value for interaction 0.014)

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