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1-adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

Semaglutide (Ozempic, Wegovy, Rybelsus) is a prescription GLP-1 medication used for weight loss and weight management, type 2 diabetes treatment, or to reduce the risk of chronic kidney disease and major cardiovascular events in certain patients with type 2 diabetes

If you're scheduled for surgery and currently on tirzepatide therapy, your surgical team and prescriber must coordinate a safe discontinuation timeline to minimize anesthesia complications and ensure optimal wound healing

In cases of serious adverse effects such as acute pancreatitis or severe allergic reactions, discontinuation is warranted with appropriate specialist referral