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Dry eye disease Dry Eye Disease (DED) is a multifactorial condition of the ocular surface characterized by a loss of tear film homeostasis, with a particularly high prevalence among individuals with diabetes (Diabetic Dry Eye Syndrome, DDES) [118,119,120,121]

However, when the glucose load exceeds the renal glucose threshold, as is the case in people with uncontrolled hyperglycemia, glucose begins to appear in the urine a clinical finding termed glucosuria

In 1970 the glucagon precursor, proglucagon, was identified

Duration and monitoring effects Most clinical trials lasted one year or less

It is, however, unclear whether patients at risk can be identified through symptoms, as discussed earlier