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Skye is conducting a Phase 2a clinical trial ( ClinicalTrials.gov: NCT06577090 ) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1
Rodent studies have shown C-cell tumours with GLP-1 receptor agonists, but the relevance to humans is unknown
2025;79 doi: 10.1016/j.eclinm.2024.103020
Retatrutide is not licensed by the MHRA or EMA and cannot be legally prescribed in the UK outside of regulated clinical trials
Bariatric surgery works, but it is invasive and carries surgical as well as lifelong nutritional risks
