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In clinical trials, non-diabetic individuals taking semaglutide experienced significant weight loss, with average weight loss ranging from 10% to 15% of initial body weight over 6-12 months of treatment

In response to these findings, the European Medicines Agency (EMA) conducted a review and concluded that NAION is a very rare adverse reaction to semaglutide-containing products, potentially affecting up to 1 in 10,000 users