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Potential Side Effects and Risks Both medications may cause similar side effects, including: Nausea Diarrhea Constipation Low blood sugar (when combined with insulin or sulfonylureas) Additional risks for Tirzepatide may include: Increased gastrointestinal discomfort during the initial adjustment period Possible allergic reactions Always report any severe or unusual symptoms to your healthcare provider immediately

As of June 2026, the FDA is in a public comment period on a proposal to formally exclude semaglutide, tirzepatide, and liraglutide from the 503B Bulk Drug Substances List

Limitations : As a case report with one patient (N=1 study), the findings are anecdotal and require corroboration through larger, controlled studies to establish broader applicability

Tirzepatide versus other ED risk factors: putting it in perspective To understand how minor any potential risk from tirzepatide is compared to other ED risk factors, consider the following comparisons: The comparison is stark

Common Adverse Effects at Diabetes Dosing When using tirzepatide at the lower doses typically prescribed for diabetes dosing, you may still experience some common side effects