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GLP-1 medications are now accessible at prices below $150 per month through PlexusDx, which offers compounded semaglutide and tirzepatide from licensed 503A pharmacies without insurance requirements

The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course

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In recent years, many payers have taken steps to limit the costs of GLP-1s and introduced limits to coverage for the use of these products for weight loss.

Tirzepatide is a 39-amino-acid synthetic peptide engineered as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors