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Indeed, acute elevated peripheral insulin levels may increase insulin in cerebrospinal fluid, whereas, chronic peripheral hyperinsulinemia (such as insulin resistance or T2DM) may downregulate insulin receptors of the BBB, impair brain insulin uptake, and ultimately lead to learning, memory, and cognitive deficits (52)

YangFLuoXLiJLeiYZengFHuangXet al

Diabetologia 61(11):23102318

Korean Society of Cardiovascular Pharmacotherapy
