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The antioxidative effects of GLP-1 receptor agonists can also be facilitated by the attenuation of lipid peroxidation, suppression of mitochondrial autophagic signaling pathways, and reduction in alpha-synuclein synthesis, which collectively lead to the inhibition of apoptosis and normalization of mitochondrial dynamic imbalance

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veterans with diabetes mapped outcomes after initiating GLP-1 RAs vs several comparators

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The author's dual-acting compound addresses this issue: the NMDA receptor antagonist (MK-801) is only activated when the drug binds to and is internalized by the GLP-1 receptor

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