glp-1 als Doctors warn drugs may speed decline Frontiers | Mini Review: Effect

doi: 10.2337/dc20-2715

GLP-1 RAs exert an antihyperglycemic effect by enhancing pancreatic -cellmediated glucose-dependent insulin secretion, suppressing glucagon secretion, delaying gastric emptying, and reducing food intake in patients with T2D [6]

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GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]