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[DOI] [PubMed] [Google Scholar] 68.Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study

She adds that some people "have significant depression with those shots," noting that some patients lose weight as fast as those who undergo bariatric surgery, which can also result in increased depression, anxiety, and suicidal ideation in patients

In a statement, a spokesperson for Novo Nordisk pointed toward Wegovy's benefits on the heart, saying that "in combination with diet and exercise, Wegovy is the only obesity medicine proven to reduce the risk of major cardiovascular events such as death, heart attack, or stroke." The results were based on 751 adults across the U.S., including Puerto Rico, who were randomized to get one of the two highest doses of either Zepbound or Wegovy

After propensity-score matching, the two cohorts (26,784 in each cohort, mean age 51.3 years, 65.6% women, 16.1% Black, 66.5% White, 6.7% Hispanic) were balanced (Table 1)

Sarcopenia as a comorbidity of cardiovascular disease