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In the Phase 3 trials, nausea was reported by approximately 44% of patients on Wegovy (semaglutide 2.4 mg) and approximately 28% of patients on Zepbound (tirzepatide 15 mg) during dose titration, usually mild to moderate and usually improving with time and dose stabilization

This makes it hard to know whether the medication is truly responsible for the side effect Why does tirzepatide cause headaches

This activation reduces appetite intensity, decreases cravings for high-calorie foods, and extends the time food stays in your stomachall factors that support calorie reduction without extreme restriction

For best results, patients should establish a routine that feels natural, rotate their injection sites , and maintain at least 72 hours between doses when changing their injection day

The glucagon receptor gives retatrutide a pronounced advantage here