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An anal fissure is a common and painful condition appearing as a small, tear near the external anal opening

Findings support semaglutide as an effective and well-tolerated option in clinical practice.Trial registration number NCT03596450.

Understanding the mechanism, risk factors, and management strategies can help patients make informed treatment decisions with their healthcare provider

GLP-1 drugs may offer mental health benefits, but caution is advised due to the risk of adverse psychological effects in some individuals.
