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This multi-receptor targeting approach has shown enhanced effectiveness in glycaemic regulation and weight loss relative to single-receptor agonists, indicating a viable route for future pharmaceutical development

Likewise, rats metabolic state is an essential factor contributing to acute stress, since caloric restriction reduces HPA axis activity [234] with lower baseline and stress-evoked plasma ACTH levels [235]

Obesity is a major health concern worldwide because it significantly increases the risk of other diseases, including heart disease, stroke, and type 2 diabetes