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Clinical trials have shown that patients on semaglutide lose an average of 15-22% of their body weight over 68 weeks, compared to 2-3% with placebo alone
The single-receptor mechanism also means fewer drug interactions and a lower risk of pancreatitis-related side effects in susceptible individuals
This combination offers potential for fibrosis regression in patients with MASH and subsequent advanced fibrosis (NCT03449446)
doi: 10.1016/j.tips.2012.05.004
