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JAMA Psychiatry Editor in Chief Dost ngr, MD, PhD, explains why his 2025 pick for Editors Choice: Clinical Trials of the Year is a randomized clinical trial showing that semaglutide is safe and effective in patients with schizophrenia who also experience overweight or #obesity and #prediabetes

There can be side effects and risks: GLP-1 drugs affect multiple systems (pancreas, kidney, GI tract) and are not without cost or health implications

Side Effects: As a GLP-1 therapy, common side effects are typically gastrointestinal, including nausea, vomiting, and diarrhea.

FDA approval is anticipated in 2026, through the FDA's national priority voucher program, positioning Lilly to compete aggressively in the oral segment